- Findings assess systems to help avoid animal testing
- Article published in Frontiers in Toxicology
The use of in vitro new approach methodologies (NAMs) to assess the potential for respiratory irritation depends on several factors, including the specifics of exposure methods and cell/tissue-based test systems. A new workshop report co-authored by the American Cleaning Institute (ACI) examines this topic in the context of human health risk assessment for cleaning products as discussed at a 1-day public workshop held on March 2, 2023. This workshop was sponsored and organized by ACI.
The report, “New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report,” is now available in Frontiers in Toxicology.
The cleaning products industry routinely ensures the safety of the products they manufacture by testing them to confirm that they do not expose consumers to any hazards, and one of these hazards is respiratory irritation. To avoid the use of animals in testing as well as to improve the accuracy of results, useful in vitro cellular-based test systems have been developed but their full benefits still need to be determined.
This report presents the workshop’s findings which will serve as a guide to the state of the science for these in vitro tests, and it will provide the cleaning products industry with the best practices and principles when selecting in vitro testing methods for their products.
“Product safety is key component of product stewardship. In the cleaning products industry, manufacturers need relevant and reliable tests to assess the potential hazards of their products so as to promote safe and responsible use,” said Francis Kruszewski, PhD, DABT, ACI Senior Director, Human Health & Safety, and a co-author of the research.
The American Cleaning Institute® (ACI – www.cleaninginstitute.org) is the Home of the U.S. Cleaning Products Industry® and represents the $60 billion U.S. cleaning product supply chain. ACI members include the manufacturers and formulators of soaps, detergents, and general cleaning products used in household, commercial, industrial and institutional settings; companies that supply ingredients and finished packaging for these products; and chemical distributors. ACI serves the growth and innovation of the U.S. cleaning products industry by advancing the health and quality of life of people and protecting our planet. ACI achieves this through a continuous commitment to sound science and being a credible voice for the cleaning products industry.